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Perhaps the earliest form of treatment was the bladder drill, an intensive intervention designed to increase the interval between voids to establish a normal frequency of urination and normalization of bladder function.
In large homogeneous populations it is possible to estimate the normal frequency of common events such as deaths and accidents.
Our model separates DR into two categories faster and slower based on the deviation from the normal frequency of grid power.
Removal of DKK1 expression allowed for a full recovery of the thymus within 4 weeks including a return to normal thymic size (Figure 3), recovery of the cortex as well as the K5K8DP progenitor population (Figure 7), and a normal frequency of both immature and mature TEC subsets defined by ΔNp63 and Aire expression, respectively (Figure 8 and 9).
The normal frequency of breathing is much higher mice (up to 200 breaths/min) compared to humans.
Mature WT SP thymocytes express high surface levels of the TCRβ and there was a normal frequency of these cells in T-PDKL155E/− thymi.
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Largely normal frequencies of mutations in both groups of patients suggest that the complex is not essential for SHM.
Flow cytometric analyses further revealed normal frequencies of CD4+CD8+ double-positive (DP), as well as CD4+ single-positive (SP) thymocytes.
These mice had normal frequencies of Treg cells in their lymphoid organs even though the majority of them lacked CD4 expression (data not shown).
A detailed analysis of Ikaros−/− mice that show evidence of ongoing thymopoiesis without bone marrow B cell development revealed normal frequencies of ETPs and absence of classical bone marrow CLPs [3].
However, CD103−/− mice do not develop spontaneous colitis and we observed normal frequencies of Treg cell populations in the mLN and intestines of naïve and Trichuris-infected WT and CD103−/− mice.
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