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In their normal conformation, prions serve a still mysterious purpose, possibly aiding memory or enhancing a cell's genetic flexibility.
The hemocompatibility improvement can be explained by the low interfacial free energy, sterically hindered effects of PEG chains, and maintaining of the normal conformation.
Co-author Kurt Wüthrich, also of the University of Zurich, says the new antibody may zero in on the dangerous PrP because it attaches to three different regions of the protein--regions which are distant from one another in the normal conformation, but are close together in the misfolded aggregate.
Similarly, glycosylation of AIDA-I is required for normal conformation and for AIDA-I mediated adhesion to epithelial cells [39].
Kidneys may be obtained either from an abattoir or from an animal killed at the laboratory, but in either case they should be collected only from calves of normal conformation and in good health.
(ii) Our model proposes that Lis1 sterically blocks a full-length linker from assuming the normal conformation on dynein's ring, keeping dynein bound to the microtubule.
Similar(43)
We present the 2.8 Å crystal structure of GTP-bound L129F mutant Rab7 which reveals normal conformations of the effector binding regions and catalytic site, but an alteration to the nucleotide binding pocket that is predicted to alter GTP binding.
PrPSc differs from the endogenous normal form (PrPc) in its conformation, partial resistance to proteolytic degradation and insolubility in the presence of detergents [ 2, 3].
The analysis of ligands in NMR models helped to quantify normal conformational fluctuations and showed a trend of increasing inter-model RMSDs with increasing conformation degrees of freedom.
Of course, there will be the normal conformational flexibility in the long alkyl chains with predominance of the all-trans conformation.
When paired with dT, the εdA is in a normal anti conformation; however, the εdA base prefers the syn conformation when placed opposite a mispaired dG.
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