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After week 6, potent topical corticosteroids (up to 30 g/week) may be used to treat symptoms and localised disease if they would have normally been used as part of normal clinical care by the physician in charge of that patient.
Serial CSF samples (frozen at −70°C) and routine clinical investigations were collected as part of normal clinical care pre-treatment and on study days 3, 7, 30, 60 and 270.
All newly diagnosed patients will have undergone ileo-colonoscopy as part of their normal clinical care.
Each group will receive normal clinical care in their respective groups.
They will receive normal clinical care, which may or may not include referral to a specialist alcohol service.
In a 10-year follow-up, patients returned to normal clinical care and no attempt was made to continue the interventions.
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Patients were treated adjuvantly according to normal protocols of clinical care.
In all cases, expression of ER, PgR and HER-2 was determined according to normal protocols of clinical care.
Finally, because this was a pragmatic study in which data were gathered during the normal course of clinical care detailed information regarding psychological factors was not obtained as this would have required patients to fill out several questionnaires.
Tissue specimens of articular adipose tissue (AAT; n = 35 63), periarticular subcutaneous adipose tissue (ScAT; n = 19 25) and synovial membrane (SM; n = 17 25) were obtained from knee joint of patients (60F/3 M) with established RA (RA stages III IV) at the time of total joint surgery, performed as a normal part of clinical care.
To find the effectiveness of lipid-lowering treatment, based on normal clinical practice in primary care, on lipid control of patients with clear hypercholesterolaemia (HC).
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