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Ursodeoxycholic acid is currently used for the treatment of primary biliary cirrhosis at 13 15 mg/kg/day, but liver tests of some patients do not return to normal at this dose.
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All the manifestations observed in diabetic rats were significantly reversed to near normal at a dose of 40 mg/kg b.w. of diosgenin.
The normal lymphocytes were found to be non-toxic at this dose.
In all patients, nitroglycerin infusion resulted in significant changes in CRT, Tskin-diff, and PI toward normal at the maximum dose of nitroglycerin: from 9.4 (0.6) seconds to 4.8 (0.3) seconds (P <0.05), from 3.3°C (0.7°C) to 0.7°C (0.6°C) (P <0.05), and from [log] -0.5% (0.2%) to 0.7% (0.1%) (P <0.05), respectively.
The health and gross appearance of livers from vTK-FVB/N mice remained normal at all GCV doses.
Tissue weight and relative tissue weight of thyroid gland was significantly (P<0.01) decreased to normal levels at dose dependent manner.
Though the extract showed no toxicity in normal rats at higher dose, the use of lower concentration in the treatment of alcoholic injury is however recommended.
It follows that AuNP did not cause any significant loss in viability for either cancer or normal cells at lower dose.
The rats were injected intraperitoneally with alloxan monohydrate dissolved in sterile normal saline at a dose of 150 mg/kg body wt [ 21].
Diabetes was induced through a single intraperitoneal injection of a freshly prepared alloxan (Sigma-Aldrich, USA) solution in normal saline at a dose of 150 mg/kg body weight.
A more recent study in rats found that tetrathiomolybdenum caused a reduction in epididymal weights, sperm concentration, motility, and normal morphology at high dose levels (Lyubimov et al. 2004).
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