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Expression of intracellular calcium-binding proteins in cultured skin fibroblasts from Alzheimer and normal aged donors.
ReTm (previously recorded at the iliac crest) were mapped in "normal" aged vertebral bodies (T11 L5 autopsy; 20 females, 10 males) and corresponding proximal femora (autopsy; 10 females).
These findings suggested that the complement pathway was activated in the normal, aged RPE/choroid.
The key to identifying these underlying factors is to characterize the phenotype of the normal, aged tissue.
The levels of proteins that participate in leukocyte extravasation and complement pathways were consistently increased in the normal, aged RPE/choroid.
Immunoblots showed the protein level of C1q, one of the components of C1, and C3, were increased in the aged tissue (Fig. 6 A), indicating the complement pathway was activated in the normal, aged RPE/choroid.
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