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Now that transcriptomes of nontraditional model systems can be readily obtained and characterized in different stages or parts of an organism (Hao et al. 2011; Siebert et al. 2011; Helm et al. 2013; Sanders et al. 2014; Schunter et al. 2014), comparing transcriptomes between species is the obvious next step.
These data are promising, and combined with the observation that the cardiodynamic response of embryonic zebrafish to many pharmacological agents is similar to those observed in mammals [ 10- 15] makes it a potentially powerful nontraditional model for studying the physiological effects of a high cholesterol diet (HCD) and its treatment through diet-based phytomedical interventions.
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"What we initially envisioned for BMG was an integrated rights company based on nontraditional models," he said.
This paper reviews two classes of nontraditional models for the (dis)equilibrium network design problem and uses these to describe research needed to advance the state-of-the art in the design of both static and dynamic networks.
The changes needed to optimize European rare lung disease therapies include a commitment to develop empowered patient communities as advocates for therapy, the development of novel trial designs with new endpoints, and for regulatory bodies to be willing to accept nontraditional models of efficacy for orphan drugs.
Because distributors are opening up to nontraditional models, including successfully self-published authors, they're starting to set measures that indie authors can reach to gain access.
Much remains unknown outside those insects, and a broader understanding of how arthropod genomes evolve requires expanding studies to include nontraditional models (Zuk et al. 2014).
"The way Starbucks built a nontraditional distribution model and made the music a lifestyle item in addition to being about music, it's very informative," he said, noting that he planned to have countertop displays in 25 to 30 local stores by early December.
Devoted to employing a nontraditional, interdisciplinary model, CGPH aims to improve health worldwide through a unique blend of global public health studies, research and practice.
However, we are confident that this tool can be used to find actionable targets as well as identify the most appropriate cell lines, particularly those that are nontraditional research models, to be used as preclinical models that more closely match tumor genotypes.
They studied a possible statistical interpretation of group-valued probabilities as well as nontraditional probabilistic models in physics and the cognitive sciences.
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