The novel nonsense type of mutation that we found enabled us to test the proof of principle that interventions designed to read through premature stop mutations may at least partially reverse a clinical phenotype.
Geisler et al. demonstrated that nearly 30% of all mutations in primary breast cancer, in particular those of the nonsense type, are not detected by IHC and that most studies evaluating p53 status by IHC have failed to show a predictive value of p53 for chemotherapy, whereas studies evaluating p53 status by DNA sequencing have reported mutations that predict resistance to chemotherapy [ 15].
An old-fashioned, no-nonsense type of British action hero.
"Distinguished guy, hard-working, dedicated, no-nonsense type of guy," he said.
There is one other mortal in the mix, Jackie Jackie van Beekk), a no-nonsense type who helps with domestic tasks.
He's a no-nonsense type of centre-forward: technically good, devastating in the air with a rocket left foot, and deceptively fast.
She's a no-nonsense type who's creating an online series, one of the many facets of Hollywood life that "Hello Ladies" implicitly sneers at.
UHURU GONJA HOUSTON Officer With Artistic Streak Although just 5-foot-6, Uhuru Gonja Houston, thickset and with a confident stride, could be mistaken for a tough, no-nonsense type in his Port Authority police officer's uniform.
One of the French ski instructors, a no-nonsense type in an all-in-one red ski suit, is doing his best to ignore the tears of one little girl while fixing the straps of a safety helmet under her trembling chin.
Andrew M. Barish, a restaurant analyst at Banc of America Securities in San Francisco, said Mr. Lewis was known as a "no-nonsense type of senior executive" who made sure managers and others at the restaurants were motivated and felt appreciated.
A no-nonsense type who modestly attributes his OBE to "other buggers' efforts", he professes to love Wiggins like a son, not least because he's "got to be able to give him a belt around the ear-hole now and then, like I would my own son".
