He makes big, bludgeoning movies stuffed with nonsense, special effects and military fetishism, and while they are ridiculous they can be absurdly entertaining when they're not boring you out of your mind.
Still, the "unlimited special effects" nonsense hides a truth or two.
It's some guy in pajama pants doing really bad interpretive dance nonsense with awful effects and a Bing backdrop.
For nonsynonymous and nonsense SNPs, their effects on translation and positions in ORF were compared with the 'list of alleles' in OMIM (e.g. described as "TRP324TER" or "ALA279THR" for the NGAS gene).
The violins were replaced by women from the New York Choral Artists, who sang in wobbly microtonal quivers and chattered nonsense syllables to hallucinatory effect.
In a similar way, nonsense verse achieves its effect by pretending to make sense, by forcing the reader to project meaning into the phonetic pattern of the jabberwocky, as one interprets the ink blots in a Rorschach test.
An aminoglycoside family of antibiotics (e.g., gentamicin) was recently reported to partially correct the effect of nonsense mutations by specifically recognizing ribosomes and by promoting a readthrough mechanism for the modulation of translation and miscoding [5].
In spite of the severe effects of nonsense mutations, the distribution of nonsense SNPs in human genes is little understood.
Although the biological effects of nonsense mutations appear to vary widely depending on their positions and the genes, the low density of nonsense SNPs that we found suggests that nonsense mutations have more disadvantageous effects than nonsynonymous mutations.
In order to understand the biological effects of nonsense SNPs, it is important to know whether they do or do not cause NMD, because premature stop codons in a gene can have distinct disease phenotypes depending on the positions of mutations [27], [38].
To elucidate the effects of nonsense mutations identified in the present study, further analysis with HCV replicating cells is necessary.
