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It's not hard to see why what Edna called the actress-singer's "diva-like nonsense" caused her to roll her eyes and double her intake of Benson & Hedges.
But after all that, you know what is arguably the strangest thing about all this nonsense caused by an IUD?
Eight mutations were nonsense, caused by a single base substitution; one was an intronic base substitution causing aberrant splicing, one caused aberrant splicing in the alternatively spliced region, located in exon 9 of the APC gene [ 21], while the remaining eight were either insertions or deletions causing a frameshift and the introduction of a premature stop codon.
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The majority of the >700 associated SCN1A mutations are nonsense causing the autosomal dominant disorder Dravet's syndrome.
To predict whether a nonsense mutation causes nonsense-mediated decay (NMD) of mRNA, we examined the locations of nonsense SNPs in the exon-intron structure of the genes (Table 6).
The majority of the compound heterozygotes had at least one known pathogenic SPG7 mutation, and both transcript and western blot analyses support a pathogenic role for the other mutations (Table 1), including novel nonsense mutations causing nonsense-mediated decay.
It was reported that in human neuroblastomas, ataxia telangiectasia and breast cancer some nonsense mutations caused skipping of exons, a phenomenon known as nonsense-associated altered splicing (Teraoka et al, 1999; Ars et al, 2000; Hastings and Krainer, 2001; Liu et al, 2001).
> -wrap-foot> kilobasesses Class I mutations result from nonsense, frameshift, or mRNA splicing mutations leading to absent CFTR production; for example, Gly542X, a nonsense mutation caused by a premature termination codon (PTC), results in an early translational defect and a truncated CFTR protein.
"The story about the haircut, even though it was a nonsense story, caused a big drop in his standing on being in touch with people," said Stan Greenberg, Mr. Clinton's pollster at the time.
Gingrich called Blitzer's question "nonsense," which caused the audience to erupt with applause.
Nemecek et al. [13] fused random yeast DNA fragments to the middle and C-terminal domain of Sup35 (Sup35MC) and selected for clones with increased read-through of the ade2-1 nonsense allele caused by elevated aggregation of the Sup35MC fusion protein.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com