Finally, after two minutes of temporizing, he arrived at a nonresponsive response that was both honest and sensible: "What is the white culture?
It is thus the magnitude of candidate gene expression within the nonresponsive G12 explants that suggests the physiological response of a primordial shoot explant, particularly during the early stages of SE induction, could determine its ability to become responsive to SE induction.
For example, DNA sequencing of the photoperiod response gene PPD-H1 in European barley landraces has revealed three distinct groups of haplotypes, two (groups B and C) with the daylight responsive phenotype found in most wild barleys, and one (group A) with the derived nonresponsive phenotype that confers adaptation to the long annual growth season of northern Europe [ 8].
It is a disease that is nonresponsive while being on salvage therapy or progresses within 60 days of last therapy.
It is a disease that is nonresponsive in patients who have never achieved a minor response with any therapy.
Lira et al. [ 27] showed that L. donovani isolated from patients in India that were nonresponsive to antimonials had 3-fold higher LD50 values than isolates from drug-responsive patients.
Nevertheless, intravenous immunoglobulin can be considered in patients with LN either as salvage immunotherapy in severe cases that are nonresponsive or nontolerant to conventional treatment or in patients who experience severe infectious complications.
In patients that are nonresponsive to bisphosphonates, Chapurlat et al. [ 11] suggested the use of IL-6 inhibitors such as tocilizumab, a monoclonal antibody used to treat rheumatoid arthritis (RA).
In relapsed ALL cases, Aplidin exerted a strong cell killing effect (97%) in all five primary cells indicating that Aplidin is a candidate antileukaemic agent in patients with ALL that are nonresponsive to standard chemotherapeutic agents.
To investigate that the adoptive transfer of IL-27R-deficient γδ T cells that are nonresponsive to IL-27 should improve anti-pneumococcal defence in WT mice with postinfluenza pneumococcal infection, γδ T cells were purified from IL-27R-deficient or WT mice by cell sorting (supplementary Fig 7), and were transferred intratracheally (i.t).
