Biomarker modulations in placebo-treated patients due to the natural history of the disease were explored and characterized using linear or nonlinear disease progression models.
In the presence of l-leucine, all of the enzyme variants displayed slow-onset inhibition kinetics (nonlinear biphasic progression curves) similar to the results seen with the wild-type enzyme.
The presented generalized mixed-effects approach for utilizing the ADAS-CogIRT scoring methodology in clinical trials is flexible and can be extended to include such nonlinear profiles of progression.
The longitudinal change in NP T2 suggested the process of IDD was nonlinear, and the significant progression occurred in 3 weeks postoperatively.
Using about two decades of semiconductor sales data, Halla worked with Dr. Amad Bahai, a professor at Stanford University, to build a complex mathematical model that incorporated chaos theory, neural networks, linear and nonlinear regression techniques and deterministic progression.
We found that rate-of-change determinations are less reliable when the observation period is 1 year or less, that dementia progression may be nonlinear when described by certain measures, and that simple change scores do not accurately characterize the rate of decline.
Progression is largely nonlinear and the game allows for emergent gameplay.
Notice that in this case the frequency shift progression was highly nonlinear.
