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In case of unsatisfactory or none response after two hours, a second dose of study medication was allowed.
Similarly, for a specific type of adverse effect (e.g., tumor development, organ toxicity, birth defects), the number or percentage of individuals in an exposed population that are effected (with each individual response converted to a quantal, or "all or none" response) will also be determined by the dose.
From this data, we conclude that cell confinement and substrate rigidity, but not Fn density or anchorage, controls actin polymerization and that the decision of a fibroblast to assemble an actin cytoskeleton is an all or none response, with some cells not responding to dimensionality at these intermediate well heights (Fig. 2D, E).
Adjusted for 10% none response, 823 participants from 21 clusters needed to be recruited.
Considering participants' compliance, none response and withdraw, a sample size of 100 per arm is needed.
The final sample size was adjusted for none response rate of 10% and it was 422.
Similar(47)
This property enables the cell to take decisions, by transforming, for example, graded stimuli into all or none responses.
Molecular titration has been shown to result in ultrasensitive "all or none" responses [ 60], which further justifies using r as the threshold and could explain the synchrony of initiation in cells containing oriC minichromosomes [ 61].
The hopes for future applications of optogenetics are high, but ChR is not the optogenetic prodigy as some advertise it, as it shows clear limitations for optogenetic use: (i) Nature employs ChR for gradual membrane depolarization, resulting in small conductance and not in the all or none responses required for efficient optogenetic use.
One then seeks to find an action potential threshold, i.e., a particular voltage value that demarcates the all-or-none response.
Many textbooks refer to excitability as an all-or-none response, i.e. a "subthreshold" synaptic input leads to a small graded postsynaptic potential while a "superthreshold" input evokes an action potential.
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