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nonaged
adjective
Not aged.
synonyms
Exact(8)
For example, as described above, the 1-minute crystal contains a small fraction of the aged sarin conjugate in addition to the dominating nonaged conjugate.
There is a residual positive electron density found at a location that is above the indole ring of Trp86 and close to the nonaged sarin (Figure 2A).
First, the inevitable reactivation/aging can significantly decrease the occupancy of the nonaged conjugate if the HI-6-exposure time is around or longer than the half-lives of sarin in the presence and absence of HI-6.
In the corresponding computed model (I3C) at the Michaelis-Menten state that was identified from the microsecond-scale MMDSs, the mobile oxime group forms a hydrogen-bond network to His447 with the oxime oxygen 5.0-Å away from the nonaged sarin phosphorus atom.
Knowing the aging half-life of sarin of ∼3 hours for hAChE [8] and the half-life of ∼4.6 minutes for sarin in the presence of HI-6, we found that 30-minute exposure to 2 mM of sarin followed by one-minute exposure to HI-6 led to a good-quality electron density map that unequivocally defines a nonaged sarin and most of the HI-6 structure.
Thus, changes in microglial distribution lead to the loss of the homogeneous arrangement of cells that can be seen in the nonaged group.
Thus, the microglial homogenous spatial distribution exhibited by the nonaged group is compromised, as illustrated by the clustering of the cells observed in the aged animals.
This discrepancy in microglia arrangement between aged and nonaged animals was further investigated, using a logistic regression model, to assess the association between microglial nearest neighbor and the animals' age.
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