Sentence examples for non-native ligands from inspiring English sources

Here, we show PgDHAR in complex with two non-native ligands, viz.

Further, our data suggest that these non-native ligands can act as the logical bootstrapping points for iterative design of inhibitors/analogs for DHARs.

We also show that, in the absence of bound native substrates, these non-native ligands help define the critical 'hook points' in the DHAR enzyme active site.

Its importance in engineering non-native ligand-binding domains is undisputed.

These studies highlight the need to distinguish between ligands that may bind under non-native conditions and those that are the true endogenous ligands.

Information regarding the interactions of non-native species of β-lg with hydrophobic ligands and the competition between β-lg and other proteins for hydrophobic ligands are poorly described in the literature.

The aim of this review is to map the current knowledge on the binding of native and non-native forms of β-lg with hydrophobic ligands, focusing on FA, as well as the subsequent biological properties of the complexes when available.

Under strongly unfolding conditions, a non-native form of cytochrome c, in which the methionine ligand is replaced by a histidine, was observed on both MP and MUA/MU SAMs.

We analyzed the trajectory in terms of changes in interface and ligand RMSD, number of native and non-native contacts and energy of each conformational state.

The results were similar for PDZ domains, with 7% non-native interactions with binding energies below the average of native PDZ-ligand-interactions, and 17% showing improved binding over the corresponding native interaction.

Table 4 Explanation of output files #Decoy Decoy number R_rmsd RMSD of receptor (protein) L_rmsd RMSD of ligand (RNA) I_rms Interface RMSD fnat Native contact fraction fnon Non-native contact fraction  .