Like other carcinoma cell lines, A549 cells are a non-homogenous cell population with several subpopulations, each with various characteristics[3], [28], [29].
However, definite conclusions could not be drawn due to methodological flaws such as small sample size, non-homogenous patient population, undefined randomisation procedures and inconsistent outcome measures.
However, the fundamental theorem of Hardy-Weinberg (H-W) law is that in large homogenous, randomly mating populations the probabilities of H-W law are preserved from generation to generation and, further in non-homogenous but randomly mating populations, they are established in a single generation after mixing [23].
However, methodological flaws as non homogenous patient population, undefined randomization process, small sample sizes, unclear outcome measurements and substantial loss of patients for follow – up, preclude definite conclusions regarding the efficacy of CAD versus CADF.
In addition, the population of patients was non-homogenous with patients treated by various agents with potentially varying degrees of success.
In the species V. cholerae, Keymer et al. [ 67] have shown that the non-homogenous marine environment drives the formation of diverse populations of V. cholerae strains, each influenced by the environment in which it lives.
Toronto's ethnically and socially diverse population will allow for the recruitment of a diverse, non-homogenous cohort of children.
The porosity distribution is also non-homogenous.
The system is completely autonomous and the robot receives no human input to pick up and stack non-homogenous rocks.
