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A diagnosis of a rapidly progressive, functional, metastatic pNET with ectopic ACTH production causing Cushing's syndrome was made, with an assumption that the tumour had evolved in its functionality from its previous non-functional status.
Over accumulation of the ECMs leads to sclerotic non-functional status of the kidney.
Hypoxia-induced p53 fails to trans-activate its target genes; recently, we have established that the cause of its non-functional status in hypoxic tumor is due to its conformational change under low oxygen concentration.
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In the case of non-functional p53 status, p73, the p53 homologue, may play a role in apoptosis induction.
Primary endpoint is number of scaphoid unions at six weeks, secondary endpoints are time interval to clinical and radiological consolidation, number of non-unions, functional status at 52 weeks and non-adherence to the treatment protocol.
As a sensitivity analysis, the non-measured functional status for those who died within 3 and 6 months was replaced by a value of 5 (poorest functionality).
The TEMPiS trial included 4428 elderly patients with acute stroke or TIA and showed that overweight and obese patients had improved survival and better combined outcomes of survival and non-fatal functional status than did normal-weight patients.
Thus even if the initial positive Contrast-value of an added reference item is decisive for non-attaining functional status, a decrease to zero or to a negative value during a subsequent visit will enhance the chance on attaining functional status at a later phase of treatment.
Non-functional, non-intuitive, and/or missing equipment.
The sequence homology between functional mouse and non-functional human FSs is shown in Figure 3.
Non-functional paralogues that often lack promoter or intron sequences.
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