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"Cell proliferation and cell death", since remodeling of damaged tissue requires proliferation of cells and removal of non-functional cell types within the damaged heart.
NSC697923 also induced cell death in the p53 non-functional cell line SK-N-AS and p53 partially functional cell line NB-19.
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This gene expression profile suggests that βlow-cells are composed of immature and/or non-functional cells in contrast to fully functional βhigh-cells.
Cells proliferate to allow growth, facilitate wound repair and replace non-functional cells.
However, if ER homeostasis cannot be restored, the UPR induces cell death pathways to eliminate non-functional cells (Walter and Ron, 2011).
PHA680632 brought about additive interaction with radiation in terms of induced cell death in p53 non-functional cells.
However, when the protein PTEN is absent or non-functional, cells experience enhanced growth, proliferation, and survival.
AML is a heterogeneous clonal disorder of haemopoietic progenitor cells where both failure to differentiate and over proliferation results in accumulation of non-functional cells termed myeloblasts [ 28].
The intrinsic apoptosis pathway senses cellular damage, including misbalanced intracellular homeostasis, oxidative stress and DNA damage, thereby triggering the cell death program to eliminate non-functional cells and to maintain tissue integrity.
Apoptosis plays an important role during brain development where it regulates cell population size and refines neuronal circuits by removing poorly connected or non-functional cells (Buss et al., 2006).
Indeed, we were only able to detect an additive effect of Aurora-A inhibition after Aurora-A inhibition and exposure to IR in p53 non-functional cells using the colony formation survival assays.
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