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A set of procedures is presented that automatically maps detailed simulation models into a hierarchy of aggregated models by hiding non-essential details and chunking chains of causal dependencies.
My suggestion is that, if you remain interested in Biology Direct as the publication venue, you substantially shorten the manuscript by dropping non-essential details and references.
I suggest to remove all non-essential details (e.g. all or, at least, part of the benchmark criteria) from the methodical part and to shift them into an appendix or supplementary text.
For comparison, we compiled four other gene sets: cancer genes, essential genes, neurodevelopment-related genes (NeuroGenes) and non-disease, non-essential genes (NDEGenes) (see details in Text S1).
Murine ES (Di Stefano et al., 2009) and LIF-iPS cells (Di Stefano et al., 2009) were cultured on feeder layer in ES medium composed by knock-out DMEM medium (Invitrogen) containing 15% fetal bovine serum (Invitrogen), leukemia inhibitor factor (LIF) (Chemicon), 2-β-mercaptoethanol, L-glutamine and non-essential amino acids (Invitrogen) as detailed in Di Stefano et al. (2009).
Non-essential members should be informed once the details are finalized.
Therefore, identification and discrimination between essential and non-essential residues can play an important role in understanding the molecular detail of β-lactamase-mediated antibiotic resistance.
The News Feed works for non-essential content shared by businesses, but if they need to reach you to work out details or modify your order, messaging works much better.
But non-essential employees at the affected departments will be furloughed starting Wednesday, while employees considered essential ― including Trump's Secret Service detail and many tens of thousands of workers in the Border Patrol, Immigration and Customs Enforcement, and the Coast Guard ― will be required to work without pay until the shutdown ends.
Detailed growth measurements were analyzed to reveal effects on ~5,500 different haploid strains that have either non-essential genes deleted or essential genes modified to generate unstable transcripts.
Non-essential jobs are cut.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com