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The main causes of non-compliance with empirical protocols have not been clearly described.
World Rugby will seek further information from the Rugby Football Union about an "apparent non-compliance" with its protocols over the handling of George North's recent head injury.
Non-compliance with sedation protocols usually leads to oversedation [ 7].
Indeed, one of the most common disruptive behaviours in the clinical workforce relates to non-compliance with organizational protocols [ 2, 14, 18, 37].
Ninety participants were eliminated from the per protocol immunogenicity cohort for HI for non-compliance with the protocol.
Of these, 239 successfully completed the trial, and one subject in the 3 8 year, 7.5 µg group was withdrawn at the Day 21 visit, before the second vaccination, for non-compliance with the protocol.
Non-compliance with medication, protocol violation or unreliable behaviour.
Study treatment continued until: disease progression; unacceptable toxic effects; the patient or physician requested discontinuation; or serious non-compliance with the protocol.
To ensure that the data reflected actual levels of physical activity in the participants, detailed screening procedures were conducted to detect non-compliance with the protocol.
Many withdrawals were not vaccine-related, most being due to employment commitments, overseas relocation or non-compliance with the protocol as a result of pregnancy.
Furthermore, in each study-group one patient discontinued the study due to non-compliance with the protocol (not willing to undergo blood sampling).
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CEO of Professional Science Editing for Scientists @ prosciediting.com