This binding to DNA is non sequence-specific and is confined to double-stranded DNA.
Conceivably, RadA, Rad51, and Dmc1 may utilize this arched basic patch for non sequence-specific interactions with anionic dsDNA.
Long dsRNA and viruses activate the interferon/RNAseL pathway, triggering a non sequence-specific degradation of cellular RNAs and apoptosis [21].
And then there she was, suddenly: a piercing sound, a sort of wailing — a white woman, wailing, picking out notes in a non-sequence.
This non-sequence-specific endonuclease activity was further characterized.
Our results show that the yeast system is a powerful cellular model to study the non-sequence-specific endonucleolytic activity of IN.
The boundary to the overlying Simsima (shallow shelf carbonate) Formation is described for the area as conformable and elsewhere a non-sequence is present (Nolan et al. 1990).
The lethal effect in yeast seems to be related to the mutagenic effect of the recombinant HIV-1 IN, most probably via the non-sequence-specific endonucleolytic activity carried by this enzyme.
A non-targeting siRNA (siCONTROL) was used as a control for non-sequence-specific effects.
Meanwhile, in order to weaken the influence from non-sequence factors, non-redundant structures from the ASTRAL95 database were chosen in our study.
Importantly, we have previously shown that the hTERT 1 300 fragment has a strong non-sequence-specific ssDNA-binding activity in vitro [28].
