The docking study on this lead compound revealed important structural requirements that need to be preserved as well as structural non-requirements that could be eliminated to substantially reduce the molecular size of the lead compound.
The advantage of ANN is its flexibility and non-requirement of standard experimental design.
The main advantages of this device are the low measurement uncertainty and the non-requirement of water-cooling.
The advantage of such method will be non-requirement of any additional hardware or may be even software unit for ID.
Importantly, as discussed next, the non-requirement for an inner mitochondrial TXN should not be exclusive of Leishmania, but instead, a feature common to all trypanosomatids.
Importantly, comparison of TXN sequences of Leishmania with those of Trypanosoma, along with an exhaustive phylogenetic analysis, strongly suggest that the non-requirement for TXN activity within the mitochondrion is also a feature of Trypanosoma.
One of the major advantages of antibody production in bacteria is the non-requirement for extensive testing for viruses and mammalian DNA, which is expensive and time consuming.
This new approach has been receiving unprecedented attention because of its advantages, including high resolution, cost efficiency, and non-requirement of pedigrees or crosses.
Peritoneal dialysis may therefore be the most viable option in young children, because of its technical simplicity and non-requirement of vascular access [ 7, 10, 12].
Consequently, aptamers have emerged owing to inherent advantages compared with antibodies, such as non-requirement of immunization from animals, more chemical and thermal stability, and less variability.
As a candidate bio-ethanol producer, Zymomonas mobilis showed some advantages, for example, higher specific rate of sugar uptake, high ethanol yield, lower biomass production, non-requirement of controlled addition of oxygen during fermentation, et cetera [ 8- 13].
