In general, most of the breakpoints are non-recurrent and generate deletions of variable size.
Follow-up time for non-recurrent and non-progressing cases were ⩾4 and ⩾5 years, respectively.
The intensity of non-recurrent and occasional pain thereby significantly differed from that of frequent and daily pain (p < 0.001).
We compared pre-treatment plasma fibrinogen levels between non-recurrent and recurrent groups of patients in each FIGO tumour stage.
Considering these factors, it is significant that only two of the earlier reported cases are non-recurrent and would qualify as a 'primary' aggressive chondroblastoma [ 5, 15].
Gender and age distribution was similar between the children with wheezing and controls, and between the children with non-recurrent and recurrent wheezing.
The study groups had distinct profiles, with induction of immune response and apoptotic pathways in the non-recurrent and metastatic/invasiveness pathways in the recurrent group.
Although all nine miRNAs showed the same trend when comparing the non-recurrent and recurrent primary groups as observed in the primary with metastasis comparison, none of the differences were significant (Supplementary Figure 3).
Although all nine miRNAs that we validated by qRT PCR showed the same trend when comparing non-recurrent and recurrent primary melanomas as observed in the primary with metastasis comparison, none of the differences were significant.
The key assumptions underpinning the self controlled case series were met, making it a good choice of design for this study; the event of interest was non-recurrent and did not lead to any substantial increase in short term mortality.
