Indeed, our analysis showed that correlations within the invariant cells during the post-event non-reactivation periods showed little increase (Figure 14A).
In contrast, these correlations should become much less similar during randomly chosen time periods of similar length chosen from the non-reactivation time points during the same post-event period.
The other situations were grouped into non-reactivation.
The changes of HBV DNA levels were grouped into two categories, HBV reactivation and non-reactivation.
ANI: anisomycin; CREB: cAMP responsive element binding protein; CREBIR: inducible CREB repressor (CREBIR) transgenic mice; IA: inhibitory avoidance; NR: non-reactivated; PR-LTM: post-reactivation long-term memory test; TAM: tamoxifen; VEH: vehicle; WT: wild-type mice.
Since this neural activity was differentially correlated with associative memory performance we assume that it could resemble the non-intentional reactivation of memory traces and not merely a neurophysiologic consequence of the intensive learning that had taken place before.
This herpes virus establishes a lifelong latent infection, interrupted by periods of non-clinical reactivation.
For instance, all the above (widened voltage window, inactivation instability and accelerated recovery) may be operative in ΔKPQ mutants [ 1], but only non-equilibrium reactivation appears to account for the APD prolonging effect observed with the Il768V mutant [ 7].
When we overlapped the potential SUMO-1 and SUMO-2/3 target TFs, we found that 74% of the TFs shared by SUMO paralogues in the non-reactivated control cells and this decreased (10%) during viral reactivation.
As shown in Table 4, there is a more significant increase in peak numbers for the top-20 SUMO-2/3 target TFs after KSHV reactivation comparing with the top twenty TFs listed from the non-reactivated control cells (Table 2).
Consistent with the ChIP-seq results, the 12 IRF binding regions tested here showed significant enrichment after viral reactivation for SUMO-2/3 but not for SUMO-1 compare to the non-reactivated control cells.
