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The classifier was constructed using siRNA instances with binary labels (potent or non-potent).
Product levels <0.3 and ≥0.3 indicated potent and non-potent siRNA, respectively.
HAB16R13 was considered non-potent against PC-12 and WRL68 (IC50(CT) of 60.0 and 40.0 μg/ml, respectively).
Extract HAB16R13 when tested against PC-12 and WRL68 showed IC50 (CT) values of 60.0 and 40.0 μg/ml respectively, which are considered to be non-potent.
The cut-off level of 0.5 was used to define positive instances (potent siRNAs with the relative mRNA level ≤ 0.5) and negative instances (non-potent siRNAs with the relative mRNA level > 0.5).
Moreover, in such cases often only the potent siRNAs are reported, leading to over-representation of potent siRNAs over non-potent, as is the case for the siRecords (SIR) database.
This promising structural core will facilitate the discovery of non-peptidic, potent NS2B-NS3 protease inhibitors to stop dengue virus infections.
From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.
Many new potent non-peptide BACE inhibitors were identified in this study.
Thus, pharmaceutical industries have focussed their efforts to find new potent, non-toxic compounds to treat bacterial infections.
A simple solvent-free protocol for the preparation of flunixin, a potent non-narcotic, non-steroidal anti-inflammatory drugs is reported using boric acid as catalyst.
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