In non-arthropod animals, closely related genes, the HES genes (hairy-enhancer of split genes) act, in most situations, as effectors of Notch signalling [ 60, 61] though some these genes do have non-Notch related roles [ 62, 63].
Many limitations, such as non-Notch specificity, dose-limiting gastrointestinal toxicity and GSI resistance, have prompted an urgent need for more effective Notch signaling inhibitors for T-ALL treatment.
The relative contributions of CSL-dependent canonical and CSL-independent non-canonical Notch activities to Notch-induced tumorigenesis have not been extensively investigated, although early studies suggested that non-canonical Notch activities might be involved [ 49].
Its characterization is (suggested) demonstrated for a (non)axisymmetric notch by using several of the smallest differences in the frequencies at which the two set of singularities occur.
We are not claiming that Angptls are non-canonical Notch ligands since that would imply Notch activation independent of Notch ligands.
Whether incorporated with NZ or not, the ratio of the stress at precrack tip of notched beam to the bending strength of non-notched beam under three-point bending fracture is less than 1.
Finally, it will be important to investigate the contributions of non-canonical Notch activities to the oncogenesis and cell survival of Notch-dependent breast cancers.
A substantial increase in the non-notched impact strength was also observed with the PLA/TKGM blend (20/80) demonstrating two times the impact strength of pure PLA.
The modelling approach is validated by simulating single fibre pullout tests with different inclination angles, notched and non-notched direct tensile tests and three-point bending beam tests with randomly-distributed multiple fibres.
A non-notched semi-circular bending (SCB) residual strength test with varying pre-loading cycles was designed to capture the residual strength of one stone matrix asphalt (SMA) mixture at 15 °C.
In addition, the variation of damage parameter, prestress degree and preparation method of concrete surface (notched or non-notched) have little effect on the bond strength and the fracture energy of the CFRP-to-concrete interface, but the interfacial maximum shear stress decreased with an increase in the damage parameter.
