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In a settlement with NASD, Ameritrade agreed to a $10 million fine related to alleged violations of Federal Reserve Regulation T, which requires customers in cash accounts (non-margin) to make full cash payments for each trade "without regard to unsettled proceeds of any securities sold".
The electrocautery artifact on each of the nine standardized re-resection margin specimens was specifically used by the pathologist to evaluate the relationship any focus of invasive carcinoma or DCIS within each standardized re-resection margin specimen to that of its actual margin surface (non-cauterized surface) and its non-margin surface (cauterized surface).
In this fashion, the distribution of electrocautery artifact on each rectangular-shaped piece of breast tissue sampled was used by the pathologist to help distinguish the actual true margin surface (non-cauterized surface) from that of the non-margin surface (cauterized surface) of each rectangular-shaped piece of breast tissue sampled.
If the lower confidence bound is greater than 0.70 (the non-inferiority margin), then non-inferiority will be demonstrated.
If the whole confidence interval of the difference between the two treatments is smaller than the non-inferiority margin delta, non-inferiority is established.
The 95% CI fell within the 10% non-inferiority margin, confirming the non-inferiority of SROM to methadone.
The major statistical requirement for choosing a non-inferiority margin is that the non-inferiority margin is small enough to exclude the effect of placebo.
The primary efficacy analysis was a non-inferiority analysis, with a non-inferiority margin of 2.0 [ 24].
The non-inferiority margin of 2.0 may appear a generous margin of non-inferiority, as apparently, a non-inferiority claim could be granted despite twice as many recurrent events.
We assessed analyses identified as non-inferiority or equivalence tests against the non-inferiority margin specified by study investigators.
Samples were taken from the non-fluorescent necrotic core, fluorescent tumour mass and non-fluorescent margin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com