Compared to non-included patients, those included were more often female and less often Caucasian, and has less severe disease (less HIV coinfection, death, less or complications), less HBeAg positive, fewer biopsies, and had received more treatment with anti viral drugs.
No major characteristics differed between included and non-included participants at re-examination (Supplementary Table S1).
Differences between included and non-included patients were tested by Independent Samples t-tests for ratio data and Pearson's Chi-Square tests for nominal data.
The included and non-included eligible children are compared by calculating differences in total participation percentages and participation percentages of specific ICPC codes with corresponding 95% confidence intervals (95%CI).
Switching between the six non-included sources and six included sources of similar size give a very similar graph, with merely 4% increment in gene count (Supplementary Figure S1).
The only significant differences observed were related to the inclusion criteria, with more metabolic risk factors, more steatosis and more advanced fibrosis in the included than the non-included patients (Table 1).
Nevertheless, the preoperative baseline status as measured by the WOMAC domains as well as the total WOMAC score was not statistically significantly different between the included and the non-included subjects (p > 0.05, data not shown).
Additionally, we did not include potential vaccination impact on non-vaccine types in our model, as the model did not include HPV types non-included in the vaccines.
A total of 9,169 ALT measurements have been performed in included and 1,310 in non-included patients.
Of the 1,300 patients seen during the study period, 1074 (83%) were included and 226 were non-included (17%) (Table 1).
