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The percentage of sickling cells increased with the extract concentration, although was non significant and non dose dependent for all extracts tested.
Serious non dose limiting haematological toxicity was only encountered in one patient at dose-level 5 with one episode of grade 3 leukocytopenia combined with grade 4 neutropenia and in one patient at dose-level 7 with one episode of grade 3 neutropenia.
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The selective iNOS inhibitor W1400 in relatively large doses inhibited in a non dose-dependent manner.
In the study of Marmugi et al. [ 50], molecular mechanisms underlying the observed responses were explored and non dose-related expression of genes involved in lipid metabolism could support their observations.
According to the WHO they classify adverse drug reactions into six types: dose-related, non dose-related, dose-related and time-related, time-related, withdrawal, and failure of therapy.
In conclusion, rhBMP-2 seems to enhance the differentiated function of canine osteoblasts in a non-dose dependent manner.
Adverse reactions are categorized into five types, the most important of which are type-A (augmented), dose-dependent, and type-B (bizarre), non-dose-dependent [4].
Biodistribution studies at 3 months postinjection showed no vector in optic nerve or visual centers in the brain and only isolated non-dose-related detection in other organs.
We previously demonstrated that exposure of male gametes to NPs causes non-dose-dependent skeletal damage in sea urchin (Paracentrotus lividus) larvae.
The results from this study showed that carbon tetrachloride caused a significant increase (P < 0.05) in serum total cholesterol which was restored to normal by the plant extract in a non-dose-dependent manner (Table 2).
Collection and analysis of 1 3 blood samples per dose may provide insight into dose-proportional or non-dose-proportional differences in systemic bioavailability, pointing towards saturation of absorption or elimination or some other phenomenon warranting further investigation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com