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Interestingly, Dlk-1 is one of the few non-conventional target genes of the Wnt pathway that were reported to be directly repressed by the TCF/β-catenin complex (Blauwkamp et al., 2008; Weng et al., 2009).
This study suggests that NF-κB activity significantly contributes to tumor hematologic and lymphatic metastases and may aid in the development of early detection methods or therapies targeting non-conventional molecular targets.
Since survivin fits the description of a non-conventional drug target, indirect strategies have been employed to interfere with its function.
Later Mario Gómez was sent into the fray as a more conventional target man.
However, with the imminence of the [Digital Economy Bill], which is set to target "non-conventional sex acts", I think it's crucial to understand how quickly this policing can flip on its own head, legislating the bodies and acts of those it deems as "non-normative" – and that's usually involving women's pleasure.
However, with the imminence of the [Digital Economy Bill], which is set to target "non-conventional sex acts", I think it's crucial to understand how quickly this policing can flip on its own head, legislating the bodies and acts of those it deems as "non-normative" – and that's usually involving women's pleasure.
Targeting non-conventional T-cell sources of IL-17A may offer an alternative strategy to reduce pathogenic macrophages in COPD.
Once activated by autophosphorylation, the first of these transducers (inositol requiring enzyme 1α (Ire1α)) directs non-conventional splicing of its downstream target, x-box binding protein-1 (XBP1) (Lin et al., 2007).
We describe potential therapeutic and intracellular applications where scaffold-specific features provide distinct advantages for targeting of non-conventional antigens and comment on the scientific progress and validation of several designed scaffolds in the voyage towards first-in-human trials.
The second algorithm uses dataflow principles, and is targeted at the non-conventional, massively multithreaded Cray XMT system.
As my colleague discussed, Presidents Obama and Piñera should endorse targeted efforts together on energy efficiency and non-conventional renewable energy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com