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However, the non biologic DMARD treatment in these groups could be altered during follow-up such that non biologic DMARD therapy could be increased, decreased, or another non-biologic treatment could be added to the current regimen all together.
Infectious events were analysed by treatment period distinguishing non biologic DMARDs (pooled) versus biologics (pooled).
The prevailing rheumatoid arthritis treatment approach comprises both non biologic (conventional) and biologic DMARDs [ 2].
Non biologic DMARDs included methotrexate, leflunomide, azathioprine, ciclosporine, hydroxychloroquine, sulfasalazine, penicillamine, cyclophosphamide and gold salts.
Of the non biologic DMARDs methotrexate is the most widely used [ 3, 4].
However, non biologic disease-modifying antirheumatic drugs (DMARDs) and more so, biologics, including tumor necrosis factor (TNF) inhibitors, seem to increase the risk of infectious events [ 1- 3].
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Early stage trials are also underway of non-biologic drugs that prevent amyloid formation.
We investigated intensification to triple therapy after initial non-biologic (nbDMARD) prescription among patients with RA.
Three drug classes that constitute the primary treatment modalities for uveitis include corticosteroids, traditional (non-biologic) immunosuppressive agents, and biologics.
The size of a bone defect, whilst important, is not an absolute indication, and options for reconstruction of large diaphyseal bone defects include biologic and non-biologic materials.
More than half (64.4%) of patients were taking a non-biologic DMARD, with 50.0% of the cohort taking methotrexate (Table 1).
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