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To facilitate nomination of the candidate genes responsible for these differences we examined the transcriptome of the tibialis anterior (TA) muscle of each strain by RNA-Seq.
However, microarray technology, used as a tool for a high throughput expression analyses, has several limitations which might have interfered with a more productive contribution of this approach to the nomination of the candidate genes.
Integration of the gene expression profiling by microarrays and QTL screening in classical mapping populations (backcross or F2) has led to identification of QTGs underlying allergic asthma [ 8] and bone mineral density [ 9], and to nomination of the candidate genes underlying adipose tissue [ 40] just to mention some of the successful attempts to identify QTGs.
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[A1.] Three senators plan to block a vote on the nomination of a candidate to head the Food and Drug Administration because of issues related to the morning-after birth control pill and condoms.
Men such as Senator Jim DeMint of South Carolina, who helped purge the party of moderates during the primaries, may or may not run themselves, but will not support the nomination of a candidate who softens the ultra-conservative message just because that might play better against Mr Obama.
The development of these data and the genome-wide correlations to brain gene expression will complement gene-at-a-time approaches to addiction through the nomination of new candidate genes and the detection of multiple interacting QTL for certain traits.
During the DPP primary election for the nomination of presidential candidate, Hsu expressed that he "will not support the candidate that opposes the construction of an underground railway system in Tainan".
Virtually all important figures in Mexican national and local politics belonged to the party, because the nomination of its candidate to a public office was almost always tantamount to election.
In a keynote speech at the party's Ard Fheis on 10 September Gerry Adams said that he felt that Sinn Féin should support the nomination of "a candidate who is capable of winning the support of progressive and nationalist opinion... who will reflect the broad republican spirit of the Irish people at this time".
Their joint support for him was announced by the UCI at the end of July but it depends on an amendment to the UCI's constitution, to allow both for the nomination of a candidate by two national federations other than his own and for a retroactive extension of the nomination period from 30 June to 30 August.
"The kingmakers have a vested interest in preventing — at all cost — the nomination of a candidate, such as Barry Goldwater, who will let the Soviet system collapse of its own internal weaknesses," Schlafly warned.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com