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Only 2 families showed nominally significant effects, but chromosome-wise significance at P < 0.05 was not obtained for either family.
We found a nominally significant genotypic association with rs7633291 and allelic association with rs1025398 alleles.
Only rs9349379 in PHACTR1 achieved a nominally significant P value (P = 0.034) (Additional file 1: Table S5).
Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P < 0.05).
The protective effect was nominally significant in the overall population.
Adjacent bin 10.3 (10q11.21-q22.1) was also nominally significant.
There were also SNPs whose effects appeared to be gender specific e.g. rs237897 (nominally significant in male subjects) and rs9840864 (nominally significant in female subjects).
FPRP calculations (Table 5) were performed for nominally significant or significant single SNP analysis results.
None of these additional SNPs showed nominally significant association to the phenotype (Table 1b).
We found 11 interactions that were nominally significant in our discovery cohort (the Marshfield PMRP biobank).
Using region-based and gene-based association analyses, we identified several loci showing nominally significant association.
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