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But he is also widely associated with the trend of nominally functional, usually one-of-a-kind collectibles known as design art — another label he dismisses.
At a time when left-leaning Bauhaus designers were busy creating minimalist, low-cost and nominally functional furniture for low-ceilinged German working class housing, the Barcelona Chair stood out as a luxurious object fit more for monarchs than the industrial proletariat.
Vaguely recognizable to each other, nominally functional, still resisting incitements to suicide, madness, or retreat from all contact with the world the city now reflects, refreshed, if that is the word, every day, with reminders that life itself is a brief scribble of being, sealed off at both ends by an infinity of eternal non-being.
Vaguely recognizable to each other, nominally functional, still resisting incitements to suicide, madness, or retreat from all contact with the world the city now reflects, refreshed, if that is the word, every day, with reminders that life itself is a brief scribble of being, sealed off at both ends by an infinity of eternal nonbeing.
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In addition, the transcriptional regulation of such factors may nominally impact their functional status as other modes of regulation such as protein stability, phosphorylation status, binding partners, and sub-cellular localization can be more important determinants of functional activity.
This is a novel association given that the rs252 delA SNP was not in high LD (r≤0.20) with other nominally associated SNPs, including two functional LPL variants rs1801177 G>A (p. (Asp36Asn)) and rs13702 C>T (resides in 3′-UTR and disrupts a microRNA-410 recognition element seed site).
In this study, statistical adjustment for birth weight did not affect the associations observed for the significant risk haplotypes in IGF1, IGF2, and IGF2R, or the single nominally significant (p < 0.05) putative functional SNP in IGF1.
To exploit any signal arising from the excess of nominally significant SNPs in the GWAS, we used ALIGATOR [16], to identify functional categories that were enriched for association signals.
The Monte Carlo p values noted here are likely to receive contributions from both the extent of linkage disequilibrium among the clustered, nominally positive SNPs and the extent of linkage disequilibrium between these SNPs and the functional haplotype(s) that lead to the association with substance dependence.
Thus, the promoter swap experiments corroborate the principle that expression of operons was dependent on the fitness conveyed by the encoded enzyme to the environmental condition and was not due to some unexpected fixed functional relation (such as an unknown signaling pathway) between the DNA sequence of these nominally generic promoter regions and the environmental signal.
We have shown that rs715212 is nominally associated with the expression of AREG and that the chromatin surrounding rs715212 is predicted to be functional.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com