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Interestingly, TARBP2, ALS2CL, P4HA1, KLK7, POR, RANBP9, Q9H693, and SCARB1 that were identified by SAM were also differentially expressed as determined by ANOVA with a nominal threshold of P<0.01.
In particular, the algorithm involves two steps: A nominal threshold of 1.25 fold change and platform p-value [11] of 0.1 were used to designate whether a gene displays differential expression in each treated and control sample relative to the averaged control pool.
A nominal threshold of P < 0.01 was defined to identify genes of potential interest for the EASE analysis.
If no wave was detected at maximum intensity stimulation, a nominal threshold of 110 dB SPL was assigned.
The only SNP that was significantly associated (nominal threshold of p < 0.05) after completion of stage 2 was CHEK2-14 (rs9608698; P-trend = 0.02).
We considered a nominal threshold of association (P < 0.05) for evaluating a shared genetic background in the 68 candidate genes to MDD between the two study populations.
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T-maps of differences in activation between the NCD-group and the noNCD-group for the three paradigms are displayed in Figure 2 at nominal thresholds of P < 0.005, uncorrected for multiple comparisons, and a voxel cluster size > 40.
The nominal threshold for the calculation of multidimensional P-values was set at a = 0.0001, from which an adjusted nominal significance level (P*) was estimated from 50 000 coalescent simulations, conditional on the SNM and the observed value of θπ.
Thus, for the resampling analysis we set a nominal p-value threshold for the McDonald-Krietman tests; enrichment is thus defined as having a significantly greater number of McDonald-Krietman tests with p-values below this nominal threshold.
After pre-loading, blocks of 106 cycles with a constant nominal stress range, ΔS, slightly larger than the nominal threshold stress range, ΔSth, are applied with increasing minimum stress, SMIN, in each subsequent block until a crack initiates.
Then, the empirical Pfa is the probability of the Gaussian random variable with fitting mean and variance larger than the specific nominal threshold η.
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