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The intervals from the LCAR model are also close to their nominal levels in most scenarios, with all but three being above 90%.
In addition, several of the upregulated SOC genes were expressed at only nominal levels in A1 or MG (Kcn15, Kcns3, Kcnk5, Kcnj8).
The effects of active proteins on TGA parameters in NHP and 8DP are shown in Figure 4. Since most of the active proteins have zero value as initial concentrations, we could not use (0.1× – 10×) nominal levels in this analysis.
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Coverage is close to the nominal level in most cases.
This may have led to coverage under the nominal level in some scenarios.
The coverage probabilities of the GPQ and MLS methods are within 0.01 of the 95% nominal level in all cases.
Nevertheless, the mid- p test did not violate the nominal level in any of the 9595 scenarios considered in this evaluation.
Type I error is lower than its nominal level in most cases for IVDL especially when τ = 0, probably due to overestimation of τ.
Even though the mid- p test does not guarantee preservation of the significance level, it did not violate the nominal level in any of the 9595 scenarios considered in this article.
The mid- p test did not violate the nominal level in any of the 9595 scenarios considered in this article and is thus an excellent alternative to the vastly more complex exact unconditional test.
All three WKM methods produces point estimates comparable to the true recurrence rate and the coverage rates comparable to the nominal level in a situation that the rate of having early colonoscopy is 30%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com