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Using a gene-based approach, we identified 17 genes with nominal burden signals.
A total of 17 genes had a nominal burden signal of association (P <0.05), most of which had two or more nonsynonymous rare variants, although they did not reach the threshold for significance after Bonferroni correction (P <1.2 × 10−4) (Table 2, Figure S5 in Additional file 1).
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Evidence (from the Bank of England here) and theory (from Paul Krugman here and Mervyn King here) suggest that when there's a shock and confidence collapses, households think less about their net worth and more about their gross nominal debt burden – specifically its relation to their expected future incomes.
In this context, it is noteworthy that ETR has a mean of 29%, which is lower than the nominal overall burden of 31.2% but still relatively high (BDI and VCI 2013; see Langkau and Rubart 2013, for comparably high levels of effective tax rates of German enterprises).
A reasonable assumption is that identification of recurrent disease at the earliest moment will allow for initiation of auxiliary therapies against a nominal tumor burden that has accumulated fewer oncogenic events.
Since, with the exception of index-linked bonds, debt obligations are set in nominal terms, its burden rises in real terms when deflation sets in.The ECB faces difficult choices, which are set out in an article in this week's print edition.
To strengthen potential generalizability, we have used both a local approach and an international approach to scope and define low back pain burden, nominal group approaches and concept mapping.
"This in turn could result in slower rates of growth of nominal incomes, increasing the burden of existing debts," the Bank of England said.
In a world of nominal declines, the real burden of the debt is increasing.In short, the risk of a debt deflation cycle has not disappeared, despite all the talk of green shoots.
This is especially bad for debt-laden households, businesses and governments in Southern Europe, which will have little scope to 'inflate away' their debt burden by increasing nominal wages," Brosens said.
We note two genes (MYO18A and SULF2) which showed nominal evidence of association on burden test (P = 6.26 × 10−7 and P = 5.78 × 10−5, respectively), but these findings are primarily driven by the small Vietnamese collection (N = 58 cases and N = 1984 controls).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com