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Without elevated noise, differentiation or de-differentiation would be blocked.
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The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be subject to experimental testing.
Reduction of EGF signaling delays the reduction of noise during differentiation and constitutive EGF activation (activated Ras) reduces noise even in progenitors.
Fluorescence time-lapse microscopy is a powerful tool in the study of genetic circuit dynamics, allowing the measurement of circuit dynamics in single cells [Suel, G.M., et al. (2007). Tunability and noise dependence in differentiation dynamics. Science315 5819), 1716 1719.].
Together with the fact that epigenetic gene silencing has a strong stochastic component [40], [41] this suggests environmentally regulated epigenetic processes as effectors of noise regulation during differentiation.
The kinetic and kinematic parameters were low-pass filtered with a bidirectional Butterworth with a 10-Hz cut-off frequency to remove noise from the differentiation process with zero-phase distortion [ 13, 25].
This suggests species-specific causal explanations for noise-dependent song differentiation which are likely associated with variation in song-copying behaviour or feedback constraints related to variable singing styles.
If the threshold is related to the noise level, and if differentiation requires a change of the threshold, then differentiation should be accompanied by a change in the noise level.
(10) Differentiation amplifies noise, therefore this method provides additional smoothing of the calculated differentiated signal, but results in the loss of the first three and last three data points of each measurement period.
Architecture-dependent noise discriminates functionally analogous differentiation circuits.
Controlling low rates of cell differentiation through noise and ultrahigh feedback.
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