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These iliac lymph nodes are indeed deep abdominal structures, but they do not constitute the majority of the bioluminescence in an anti-HSV amplicon response, as we showed previously [11].
Therefore, we think that it is important to analyse whether detected lymph nodes are indeed metastatic (by using FNA), particularly if this will affect a treatment decision in patients.
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Differently, in large networks this blinking containment strategy loses its efficacy: the advantage of randomly sending inputs to all the network nodes is indeed canceled out by the slow propagation of these signals across the network.
An ESM that does not contain any composite nodes is indeed a simple path.
We have conducted a number of numerical simulations (data not shown) that indicate that for randomly simulated DAGs the ordering of the nodes is indeed well reflected in the partial variances, as expected.
Computed tomography and/or FDG-PET can be used to confirm that an enlarged regional lymph node is indeed metastatic, as the number of false-positive results was found to be relatively low for both investigations.
Lymph nodes draining inflamed joints are indeed selectively characterized by local differentiation of CD23+CD21highCD1dhigh B cells (a population defined "Bin", B cells in inflamed nodes) [ 81, 82].
Following the addition of novel taxa, no new clear-cut case of LGT could be observed with respect to these nodes, confirming that transfers are indeed very rare for these markers[ 5, 11].
Bottlenecks are, indeed, key connector nodes with properties that relate to the function and dynamics in interaction networks.
This prediction is further supported by a significant negative correlation between branch length and node depth, suggesting that longer branches are indeed found deeper in the tree (note that without considerable rate heterogeneity it would be difficult for a long branch to be shallowly placed).
The maximal node matching for the random graphs (generated based on the Erdos Renyi model) with randomly assigned node weights (results analyzed in Sect. 5) incur an assortativity index close to 0 to vindicate that the maximal node matching is indeed independent of node weights.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com