Sentence examples for no uncoupling from inspiring English sources

DR is associated with disorders in the nitric oxide (NO) pathway including impaired NO-mediated vasodilatation, increased oxidative stress, dysregulation at NO synthase isoforms, and NO uncoupling.

Pathogenesis is multifactorial and includes excessive generation of reactive oxygen species that interact with and consume nitric oxide (NO), generating peroxynitrite and resulting in oxidation of tetrahydrobiopterin and promotion of NO uncoupling.

Thus, the levels of uptake of radiotracer forms of l-pipecolic acid and glycine are comparable to the relative levels of current induced by the two compounds demonstrating that there is no uncoupling of PAT2 transport.

The bioavailability of NO is dependent on the presence of reactive oxygen species (ROS) that oxidize NO and uncouple NOS, preventing NOS from producing NO [ 5].

Exposure of EPCs to HG concentrations increases NAD(P H oxidase activity which results in increased O2- generation and reduced NO bioavailability because O2- inactivates NO and uncouples eNOS [ 12].

EPCs have high intracellular expression levels of SOD, which can protect them against oxidative stress [ 47].Thum et al have reported that increased NAD(P H oxidase activity results in increased O2- generation and reduced NO bioavailability because O2- inactivates NO and uncouples eNOS in EPCs [ 48].

The combination of increased oxidative stress and impaired NO signaling resulting from NOS uncoupling has been implicated in the pathogenesis of a wide range of disease states, including atherosclerosis [ 7], hypertension [ 8, 9] and diabetes [ 10].

Similarly, although no evidence of eNOS uncoupling was observed in hph-1 lung tissue alone, striking eNOS uncoupling and BH4 oxidation were discovered when both the synthetic and the recycling pathways were diminished.

Gwyneth Paltrow and Chris Martin's 'conscious uncoupling' was no different.

Excessive ROS production also induces a dysfunctional eNOS, or referred as eNOS uncoupling, which generates superoxide instead of NO [ 3, 15].

Although rosuvastatin significantly reduced VLDL apoC-III PR, there was no impact on VLDL apoB PR (13), suggesting an uncoupling of this association.