Suggestions(1)
Exact(8)
However, NO suppresses NLRP3-mediated but not NLRC4- or AIM-2-mediated ASC pyroptosome formation (Supplementary information, Figure S9).
These data provide clear evidence that NO suppresses NLRP3 inflammasome-mediated IL-1β secretion and caspase-1 activation in mouse macrophages.
Furthermore, basal activity of soluble guanylyl cyclase (sGC), an intracellular receptor for nitric oxide (NO), suppresses apoptosis in ovarian cancer cells, partly via inhibition of p53 accumulation and activation (Fraser et al, 2006).
Since NO suppresses platelet aggregation as well as vascular release of TXA2, NO-deficiency is often associated with activation of TP-receptors.
Since endothelium-derived nitric oxide (NO) suppresses constitutively the release and vascular effects of thromboxane A2 (TXA2), NO-deficiency is often associated with activation of thromboxane receptors (TP).
These results show that NO suppresses the cell cycle in early G2/M by triggering a highly integrated program of gene regulation that does not require soluble guanylate cyclase or cGMP.
Similar(52)
Recently, Kazlowska et al.[ 28] suggested that the inhibition of iNOS in the RAW 264.7 cell is due to the NO suppressing action of flavonoid and phenolic compounds such as rutin and cathecol.
As part of the biochemical program that facilitates blood flow and maintains vascular homeostasis, NO normally suppresses the expression of VCAM-1, ICAM-1, and E-selectin.
In KRC/Y cells the mutated gene had a significantly reduced growth suppression activity (Figure 4A) while in LNCaP it had almost no suppressing activity (same as the empty vector, see [16], [17]).
Additionally, IMM-H004 significantly suppressed the release of TNF-α, IL-1β and NO, and suppressed the expression of pro-inflammatory mediators and cytokines such as iNOS, COX-2, and IL-6 in LPS-stimulated BV2 microglia.
However, if 15 min LFS delivered intermittently by 5 min interval, it had no suppressing effect on kindling rat.
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