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Engelman et al (2008) found no substantial response of KrasG12D-driven NSCLC to PI3K-mTOR inhibition by NPV-Bez235 in vivo.
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Instead we have oscillated from arguing that climate change does not need a substantial response, to introducing policies such as Direct Action that have no perceived impact on consumers and limited impact on the environment, to advocacy for an immediate transition to cheap, job-creating renewable electricity.
Mr. Levy said he expected to see a substantial response from the F.B.I. in the coming days.
It would be a meaningful and substantial response to the scale of human suffering we see daily.
"I think we're going to see a substantial response," Mr. Hannah said.
The chairman of the PCC surely ought to be offering more than misleading soundbites in response, and we look forward to a more considered and substantial response.
Mr. Pan's lawyer, Irwin Rochman, said, "We will have a substantial response to the indictment in the near future".
Though the committee welcomed the government's focus on measures to reduce youth unemployment, it said it was too soon to judge whether they were a "sufficiently timely and substantial response" and vowed to monitor their effectiveness closely.
So the simple, if substantial response of the Canada Mortgage and Housing Corporation, the government housing finance agency, involving an increase to market liquidity rather than any actual investment in the banks, proved adequate to alleviate the Canadian financial sector's problems.
Users were clearly bothered, so yesterday OnePlus provided a more substantial response on its support forums.
But a week later, Apple has yet to pull the app or give any kind of substantial response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com