Sentence examples for no substantial alteration from inspiring English sources

Post-biopsy mammography usually shows no substantial alteration in the target lesion with conventional 14-gauge needles.

In conclusion, the combination of figitumumab at a maximum feasible dose of 20 mg kg 1 and docetaxel at 75 mg m 2 is safe and well tolerated in patients with advanced cancer, with no substantial alteration in the PKs of either agent.

A recent study from the International Children's Accelerometry Database (ICAD) 1 examined a range of cut points for associations with other factors and found that there was no substantial alteration to associations as a function of choice of accelerometer cut point.

In the susceptible NIL Bowman, no substantial alterations of RuLC and RuACS were observed.

There were no substantial alterations of Bcl-2, Mcl-1, Bak, Noxa, Puma protein levels in response to paclitaxel treatment.

PC3 cells exhibited no substantial alterations in signaling which is consistent with previous reports where PC3 cells had minimal to no AR expression [ 23].

Interestingly, no substantial alterations in constitutive JNK1/2 and p38 MAPK were determined, whereas phosphorylated p38 MAPK form rose. Contrariwise, 27 h E-4IB/cisplatin treatment was linked to an enhanced phosphorylation of both JNK and p38 MAPK.

Studies of non-small cell lung cancer patients and breast cancer patients found no substantial alterations in vWF Ag levels compared to reference controls [ 22, 23], and a clinical trial of human patients with colorectal cancer found significantly elevated levels of plasma vWF but was unable to clearly define the related role in cancer progression [ 24].

However, we did not observe any substantial alteration in Xenopus heart size following overexpression of Xic1 or Xic1 mutants thereof (Supplementary material online, Figure S3B ).

Jerry Hewes, Mayville, New York   Research has shown that epigenetic changes can result in substantial alteration in when and how genes are expressed based on our interactions with our environment.

The changes, which are shaping up to be the most substantial alteration ever to a campaign calendar in a single election cycle, have heightened the volatility of the most wide-open presidential race in 50 years, one with large and well-financed fields of contenders.