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Metformin appeared to produce an almost total inhibition of oxygen uptake with no subsequent stimulation by DNP.
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Previous studies have shown that cells that undergo prolonged stimulation of Nod2, mimicking prolonged infection, no longer respond to subsequent stimulation by bacterial ligands, such as LPS, thus becoming tolerant to those stimuli [32], [54].
Partial heterologous desensitization occurred, when BK was used as the first agonist, whereas NPY had no effect on a subsequent stimulation with BK.
Consequently, local thermal borehole enlargement reduces project failure risks by providing better control on subsequent stimulation processes.
Calcineurin-interacting protein kinase is important for the detection of the Ca2+ signal and the subsequent stimulation of the downstream phosphor-signaling cascade.
HIF-1α activation contributes to the metabolic reprogramming of cancer cells by impairing mitochondrial phosphorylation and the subsequent stimulation of aerobic glycolysis.
Taken together, our data demonstrate that through the identification and subsequent stimulation of genes, proteins and signaling pathways associated with calcium phosphate mediated osteoinduction, a focused approach to develop targeted differentiation protocols in adult progenitor cells can be achieved.
However, treatment of rat neutrophils by TNFα and their subsequent stimulation with fMLP resulted in enhanced ROS production.
Stalled replication forks activate the Ub-conjugase/ligase Rad6/Rad18 complex to mediate PCNAK164-specific ubiquitylation and subsequent stimulation of DDT.
Finally, as a test of long-term memory, we observed whether prior stimulation alters the rate at which the reversal circuit habituates to subsequent stimulation [17].
SSA therefore embodies a short-term memory trace that determines the response of the neuron to subsequent stimulation [7], [42], [43].
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