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However, it must be stressed that PCI is not a disease but a physiological reaction to several conditions; hence, there is no single etiology [4, 9].
As for many other neurodevelopmental disorders no single etiology of ADHD has been provided, but a number of underlying theories exist.
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Anxiety represents a heterogenous group of disorders, probably with no single unifying etiology; various psychodynamic, psychoanalytic, behavioral, cognitive, genetic and biological theories have been proposed to explain the etiology of anxiety disorders [ 1].
It would be optimal to carry out an exploratory analysis on single etiology.
CAS is the leading single etiology of valve disease necessitating replacement, accounting for a major fraction of the approximately 300,000 valve replacement surgeries worldwide each year [7].
These subjects were grouped into the "other" category because a single etiology could not be chosen.
Unlike clinical AKI, animal models can be used to explore single etiology.
The single etiology or comorbidity is predominant in younger patients, while multiple etiology or comorbidity is predominant in the elderly.
The most common single etiology was vavular heart disease, the most common triple etiology was coronary artery disease complicated with hypertension and diabetes mellitus.
This is not surprising as many studies have shown that ALS is an heterogeneous spectrum of diseases rather than a single disease with a single etiology.
Therefore, an investigation on cases with a single etiology will be critical for understanding the molecular mechanism responsible for this high heterogeneity in disease phenotypes.
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