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In contrast, there was minimal or no sensitization of the LN-18 cells to TMZ after transfection with the control scL-vec, again demonstrating that the response in these resistant cell lines is due to the presence of exogenous wtp53 and not nonspecific cytotoxicity.
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The reduction of the parasympathetic contractile response in CYP-treated rats depends partly on an increased production of nitric oxide (NO) due to sensitization of urothelial muscarinic receptor stimulated NO effects [ 6, 14, 15].
Experimental evidence against aura as a trigger of migraine pain comes from two studies in which there was no activation or sensitization of second-order neurons in TNC by CSD [66, 67].
Despite the fact that mast cells have CGRP receptors [9, 10], no activation or sensitization of meningeal nociceptors could be detected upon topical or systemic administration of this compound in rats [8].
In addition, no sensitization was observed by downregulation of Mcl-1 (Fig. 4).
These findings suggest that DAHP (presumably via inhibiting endothelial NO production) induces a sensitization of the cGMP response, a phenomenon that might be related to the NO supersensitivity of blood vessels treated with NO synthase inhibitors [26].
However, the experiment results also indicate weak optical activity of Ti0.91O2/CdS hollow sphere nanostructures under a 400-nm laser excitation and no obvious occurring of sensitization of CdS on Ti0.91O2.
According to the proposed model, the mutual sensitization of the oxidation of methane and NO proceeds through the NO to NO2 conversion by HO2 and CH3O2.
Moreover, there is no evidence presented that stimulation of nociceptive afferents induces bradykinin-dependent sensitization of motoneurons.
There was no variability observed from donor to donor with respect to mature DCs production and sensitization of T-cells.
Thus photocatalysis predominately takes place via sensitization of Bi2O2CO3.
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