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This might also explain why anti-TNF-antibodies were very effective in improving patients' symptoms, while no relevant alteration of IFN- γ mediated tryptophan degradation was observed [ 29], and neopterin concentrations did not differ before and under adalimumab treatment in our patients.
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We found systemic changes in capillary pH and pCO2 levels but no relevant alterations beyond the normative range and conclude that nasal application at 1 l/min is safe.
While liver fibrosis was seen in thioacetamide-treated rats (p<0.001), kidney histology showed no relevant alterations in any of the groups.
Overall numbers of myelinated fibres showed no relevant alterations in all examined nerves and genotypes.
Vancomycin hydrochloride solutions diluted at 10 mg/ml presented a clinically relevant alteration when infused during 120 min, despite the analyzed temperature.
Issues regarding adjustments for multiple testing, statistically significant thresholds, and biologically relevant alteration levels, have not been established for high-throughput DNA methylation studies.
Third, does the gene polymorphism produce a relevant alteration in the level or function of the gene product?
Furthermore, a clinically relevant alteration of hemostasis in subjects suffering from AMS was not detected during exposure to hypoxia.
Seventeen fetuses were observed to carry a clinically relevant alteration, including 11 sex chromosome aneuploidies and six recurrent microduplication syndromes.
Finally, based on the literature review, a threshold of 15% was used in order to include the patients with a clinically relevant alteration in FO.
Conversely, the only clinically relevant alteration missed by CMA was a triploidy with karyotype 69, XXX, associated with a usually lethal condition in utero.
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