A biologic rationale exists for the association between metabolic syndrome (MetS) and prostate cancer (PCa).
Although a similar rationale exists for the regeneration of articular cartilage with bioactive factors, advancement in this area has not been as substantial.
However, a clear rationale exists for providing long-term, controlled release of vaginal microbicides in order to afford continuous protection against heterosexually transmitted HIV infection and to improve user compliance.
Not unlike in estrogen receptor-positive breast cancer, mechanisms of resistance are being investigated and rationale exists for thoughtful, well-designed combination regimens such as AR antagonism with CDK4/6 pathway inhibitors or PI3K inhibitors.
Moreover, a compelling mechanistic rationale exists for each gene identified.
Therefore, a rationale exists to use BH3 mimetics to circumvent apoptosis resistance in these cancers.
An underlying biologic rationale exists to support an etiologic role for physical activity in endometrial carcinogenesis.
Hence, a simple physiologic rationale exists for using carbon dioxide monitoring to obtain information about cellular metabolism and global perfusion.
A pathophysiological rationale exists for MH as a secretion-clearance technique that should be tested in clinical trials.
As OS is a highly vascularised tumour, a rationale exists to use this feature as a therapeutic target.
