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No obvious alterations was observed in H3K56Ac, an acetylation mark of newly synthesized H3 (Li et al., 2008), which was analyzed by ChIP assays side by side (Fig. 2E, right panel).
Both MKS1 and MKS3 mutant animals show no obvious alterations in odor receptor expression.
Mef2-Gal4>UAS-C3GDN flies were viable and showed no obvious alterations in actin organization (Figure 6B).
As shown in Fig. 1, in wild-type nematodes, no obvious alterations of head thrash were recorded in nematodes treated with heat-shock for 0.5 h.
Although as discussed above (Fig. 2D, F), no obvious alterations in hair cell differentiation were observed, hair cells patterning was found to be occasionally disrupted.
No obvious alterations in the distribution and morphology of supporting cells (indicated by Hoechst stained nuclei), or in the size of the utricle were identified in these conditional mutant embryos (Figs. 2,3).
Similar(35)
However, no obvious alteration in HDAC1 protein levels was observed.
As shown in Figure 5b and quantitated by densitometry (data not shown), no obvious alteration was observed by any given treatments under our experimental conditions.
Moreover, there is no obvious alteration of the absorption intensity for OBHJ films between the nanograting line directions parallel and normal to incident light direction.
The inclusion of HA into the hydrogel led to the formation of small aggregates distributed throughout the hydrogel, with no obvious alteration of the pore structure outside the aggregates.
Despite differences in these values, V287R produced no obvious alteration in macroscopic inactivation kinetics at potentials where the channel was nearly or fully activated.
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