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However, no obvious alteration in HDAC1 protein levels was observed.
As shown in Figure 5b and quantitated by densitometry (data not shown), no obvious alteration was observed by any given treatments under our experimental conditions.
Moreover, there is no obvious alteration of the absorption intensity for OBHJ films between the nanograting line directions parallel and normal to incident light direction.
The inclusion of HA into the hydrogel led to the formation of small aggregates distributed throughout the hydrogel, with no obvious alteration of the pore structure outside the aggregates.
Despite differences in these values, V287R produced no obvious alteration in macroscopic inactivation kinetics at potentials where the channel was nearly or fully activated.
However, we detected no obvious alteration in the fraction of Drp1 that distributes with mitochondria in park25 or PINK1B9 mutants relative to wt controls (Figure 2E), although this experiment revealed that the higher MW form of Drp1 appeared to preferentially localize to mitochondria in both wt and mutant samples.
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No obvious alterations was observed in H3K56Ac, an acetylation mark of newly synthesized H3 (Li et al., 2008), which was analyzed by ChIP assays side by side (Fig. 2E, right panel).
Both MKS1 and MKS3 mutant animals show no obvious alterations in odor receptor expression.
Mef2-Gal4>UAS-C3GDN flies were viable and showed no obvious alterations in actin organization (Figure 6B).
As shown in Fig. 1, in wild-type nematodes, no obvious alterations of head thrash were recorded in nematodes treated with heat-shock for 0.5 h.
Although as discussed above (Fig. 2D, F), no obvious alterations in hair cell differentiation were observed, hair cells patterning was found to be occasionally disrupted.
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