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No major abnormalities were noted in terms of electrolytes, blood glucose, renal function and liver function tests.
Though we did observe some axonal retraction and occasional swollen dendrites, the ganglion cells showed no major abnormalities (see Figure 1 C G).
No alterations in weight were observed in caCnRIP mice suggesting that there were no major abnormalities in appetite control by expression of the transgene in the hypothalamus (data not shown).
This could be due to the immune response against adenovirus or toxicity of Cre, even if no signs of pathological responses were found in clinical chemistry or histological sections; apoptotic cells were present in all livers transduced with AdCre, but also in the control mice (data not shown) and no major abnormalities were seen (ASAT and CRP) between the groups (Figure 3B and C).
The other organs showed no major abnormalities on microscopy.
No major abnormalities in calcium metabolism were evident.
Similar(45)
Their close similarity is not surprising, no major abnormality was found.
No major abnormality of mitochondrial DNA copy number was detected in muscle DNA from any of the patients with compound heterozygous SPG7 mutations (Table 1).
Post-study gross necropsy and histopathologic evaluation of all participating rabbits did not reveal any major abnormalities.
The bmr mutants that were part of this study did not show any major abnormalities in their growth and development.
In addition, the microscopy studies did not detect any major abnormalities in the apicoplast morphology during its growth and division in the late schizont stages.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com